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Research Overview

RESEARCH PROFILE:

Vigneshwar Kasirajan, MD

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Research Profile: CARDIOTHORACIC SURGERY


Vigneshwar Kasirajan, MDVigneshwar Kasirajan, MD

Professor & Chair, Department of Surgery, VCU School of Medicine
Director of Heart Transplantation, Heart-Lung Transplantation & Mechanical Circulatory Support, VCU Pauley Heart Center

Curriculum Vitae (Feb2017)

Clinical Trials

 

heart transplantRESEARCH LABORATORIES

Dr. Kasirajan and Dr. Quader’s labs (with other investigators from the Division of Cardiothoracic Surgery) are involved in studies to benefit the heart surgery and the heart transplant patient.

A shortage of donor hearts for transplantation severely limits the use of cardiac allo-transplantation as a cure for end stage heart failure. The lab studies ways to use hearts from donors that otherwise were considered unusable in order to expand the donor pool. Unwanted hearts are brought to the lab in hopes of reanimating them to a functional state consistent with supporting a transplant. Warm perfusion with blood or solutions and other experimental protocols are used and developed to affect reanimation and repair.

After the reanimation period, the hearts are  tested on a working heart device to demonstrate that they have regained function and are now suitable for transplantation in patients. In addition to using human hearts turned down by the transplant service, the lab uses large and small animal models to explore mechanisms and experimental conditions of heart reanimation, repair, and preservation.

Heart

Experiments to re-energize donor hearts through experimental biogenesis is also ongoing in the lab. In these studies, hearts are treated with experimental conditions that are designed to increase the production of new mitochondria in the myocardial cells during the preservation period. which will aid in the reanimation and repair process and allow the hearts to function normally immediately after transplantation.  Mechanisms that lead to reanimation, repair, preservation, and biogenesis are explored in basic cell and organ studies.

Other research interests of the Cardiothoracic Surgery research labs include the development and testing of better cardioplegia solutions and the testing of device implants for the heart patient (LVADs, Pacemakers, valves, and grafts).

CONTACT INFORMATION

P.O. Box 980068
Richmond, VA 23298-0068
vigneshwar.kasirajan@vcuhealth.org

Dr. Kasirajan's Faculty Bio

 

CLINICAL TRIALS

GRANT # DESCRIPTION SPONSOR TOTAL AWARD
5150448FF Randomized Evaluation of VAD Intervention Before Inotropic Therapy (REVIVE-IT) University of Michigan 19,535
5100281IN RA-142: SynCardia Freedom Driver System Study SynCardia Systems 236,383
5100350IN Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients...Protocol #ROADMAP Thoratec Corp 58,572
5100392IN AtriCure Synergy Ablation Lesions for Non-Paroxysmal Forms of Atrial Fibrillation Treatment during Concomitant On-Pump Endo/Epicardial Cardiac Surgery AltriCure, Inc 33,250
5400181IN Pivotal Study of Dual Epicardial & Endocardial Procedure (DEEP) Approach for Treatment of Subjects with Persistent or Long Standing Persistent Atrial Fibrillation with Radiofrequency Ablation AtriCure, Inc  23,731
5400193IN HeartMate III Thoratec Corp 19,100

 

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